Fresh analysis indicates that people who come off blockbuster slimming jabs like Mounjaro or Wegovy can put back on lost weight much more quickly than those who end conventional lifestyle plans.
Findings released in a prominent medical journal points out that while obese people can lose about a fifth of their body weight while using the jabs, the weight comes back at an average rate of 0.8 kg per month upon discontinuation.
"Individuals buying these medications must be cognizant of the danger of quick rebound weight gain when the therapy concludes," stated expert Dr. Susan Jebb.
This pace of recovery means a reversion to pre-treatment weight within about 18 months.
Analyzing Approaches
The analysis, which examined 37 of trials involving over 9,000 of patients, contrasted the effects of GLP-1 agonists with other pills.
Researchers note that people who lose weight through dieting generally experience a slower creep back—approximately 0.1 kg a month—post-intervention.
Understanding the Quick Rebound
Nutrition scientists suggest the way of the drugs is key to understanding the accelerated weight return.
These medications copy a natural hormone called glucagon-like peptide-1, which helps regulate hunger.
"Artificially providing GLP-1 concentrations several times higher than the body's typical production could lead to the system to produce less of its own natural GLP-1, and could lessen responsiveness to its actions," said Dr. Adam Collins, a dietetics expert.
"Stopping of this hormone supplement results in hunger is no longer kept in check, making excessive eating a significant risk."
A Lifelong Condition?
The NHS suggest the jabs for individuals with weight-linked health risks, accompanied by recommended diet and exercise modifications.
Many experts contend that, considering the likelihood of weight regain, the treatment might need to be ongoing.
This perspective is echoed by pharmaceutical companies, who note that the results "underscore the chronic nature of excess weight," comparing it to managing conditions like hypertension.
User Accounts
Users who have stopped the medication explain a sudden return of cravings.
"It was like a switch activating and I was suddenly extremely hungry," recalled an individual.
This difficulty is worsened if individuals have not adopted permanent lifestyle or habit changes during treatment.
Widespread Use
Recent estimates indicate that a significant number of adults in the UK have used weight-loss jabs in the past year, with desire remaining high.
- Adoption is greater among women compared to men.
- The 40s and 50s demographic shows the greatest level of interest.
- Many obtain the drugs through private prescriptions rather than the NHS.
In conclusion, clinicians stress that while GLP-1 drugs are powerful agents for weight loss, they are not a standalone solution and maintained weight loss relies on combined behavioural changes.
